This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Harkness, J.E. & Wagner, J.E. The Biology and Medicine of Rabbits and Rodents 4th edn (Williams & Wilkins, Baltimore, MD, 1995).
Percy, D.H. & Barthold, S.W. Pathology of Laboratory Rodents & Rabbits 2nd edn (Iowa State University Press, Ames, IA, 2001).
Schaeffer, D.O. & Donnelly, T.M. in Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery (eds Hillyer, E.V. & Quesenberry, K.E.) 260–281 (WB Saunders Co, PA, Philadelphia, 1997).
Loeb, W.F. & Quimby, F.W. The Clinical Chemistry of Laboratory Animals (Taylor & Francis, New York, NY, 1999).
Berger, J., Shepard, D., Morrow, F. & Taylor, A. Relationship between dietary intake and tissue levels of reduced and total vitamin C in the nonscorbutic guinea pig. J. Nutr. 119, 734–740 (1989).
Mahmoodian, F. & Peterkofsky, B. Vitamin C deficiency in guinea pigs differentially affects the expression of type IV collagen, laminin, and elastin in blood vessels. J. Nutr. 129, 83–91 (1999).
Peterkofsky, B. Ascorbate requirement for hydroxylation and secretion of procollagen: relationship to inhibition of collagen synthesis in scurvy. Am. J. Clin. Nutr. 54, 1135S–1140S (1991).
Kipp, D.E., McElvain, M., Kimmel, D.B., Akhter, M.P., Robinson, R.G. & Lukert, B.P. Scurvy results in decreased collagen synthesis and bone density in the guinea pig animal model. Bone 18, 281–288 (1996).
Roomi, M.W. & Tsao, C.S. Effect of ascorbic acid deficiency on plasma prothrombin time and partial thromboplastin time in guinea pigs. Clin. Chim. Acta 248, 209–211 (1996).
Schwager, J. & Schulze, J. Modulation of interleukin production by ascorbic acid. Vet. Immunol. Immunopathol. 64, 45–57 (1998).
Majumder, M.S.I. & Abdur Rahim, A.T.M. Cell-mediated immune response of scorbutic guinea pigs. Nutr. Res. 7, 611–616 (1987).
Goldschmidt, M.C., Masin, W.J., Brown, L.R. & Wyde, P.R. The effect of ascorbic acid deficiency on leukocyte phagocytosis and killing of actinomyces viscosus. Int. J. Vitam. Nutr. Res. 58, 326–334 (1988).
Institute of Laboratory Animal Resources, National Research Council. Guide for the Care and Use of Laboratory Animals (National Academy Press, Washington, DC, 1996).
Groves, M.H. Hypovitaminosis C in the guinea pig. Vet. Rec. 131, 40 (1992).
Clarke, G.L., Allen, A.M., Small, J.D. & Lock, A. Subclinical scurvy in the guinea pig. Vet. Pathol. 17, 40–44 (1980).
Barnes, M.J., Constable, B.J., Impey, S.G. & Kodicek, E. Mortality rate in male and female guinea-pigs on a scorbutogenic diet. Nature 242, 522–523 (1973).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Hickman, D., Wasson, K. & Ehrhart, E. Diagnosis: Subclinical Hypovitaminosis C. Lab Anim 32, 24–25 (2003). https://doi.org/10.1038/laban1003-24
Issue Date:
DOI: https://doi.org/10.1038/laban1003-24