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Poor replicability in animal research can be a result of low external validity driven by rigorous standardization of study populations. This study investigates how heterogenization of study populations by using mice from different breeding sites might affect the replicability of animal studies conducted in a single facility. The findings suggest that heterogenization by breeding site has limited capacity to improve replicability in animal research.
Environmental enrichment is a home-based intervention that mimics natural habitats for laboratory-housed animals. This systematic review of 27 environmental enrichment protocols finds consistent benefits for zebrafish welfare while raising the importance of a standardizing protocol to improve reproducibility of results.
Fernandez, Martinez-Romero et al. review concepts, methods, tools and challenges to leverage Big Data in preclinical aging research, with a focus on rodent studies.
The authors used a gene-editing approach to generate a C57BL/6J mouse model expressing the CD45.1 epitope. The model, which overcomes some of the issues reported with the congenic mouse B6.SJL, could be useful for adoptive cell transfer experiments.